ميكوفينولات 500مجم 50 اقراص

ما هو دواء ميكوفينولات 500مجم 50 اقراص

جرعة دواءميكوفينولات 500مجم 50 اقراص

يستعمل دواء ميكوفينولات 500مجم 50 اقراصmycophenolate mofetil-sandoz 500 mg 50 tabs. immunosuppressant immunosuppressant

indication -for the prophylaxis of organ rejection in patients receiving allogeneic renal cardiac or hepatic transplants. mycophenolate mofetil should be used concomitantly with cyclosporine and corticosteroids. - -mechanism of action -mycophenolate mofetil is hydrolyzed to form mycophenolic acid (mpa) which is the active metabolite. mpa is a potent selective uncompetitive and reversible inhibitor of inosine monophosphate dehydrogenase (impdh) and therefore inhibits the de novo pathway of guanosine nucleotide synthesis without incorporation into dna. because t- and b-lymphocytes are critically dependent for their proliferation on de novo synthesis of purines whereas other cell types can utilize salvage pathways mpa has potent cytostatic effects on lymphocytes. mpa inhibits proliferative responses of t- and b-lymphocytes to both mitogenic and allospecific stimulation. addition of guanosine or deoxyguanosine reverses the cytostatic effects of mpa on lymphocytes.

تركيبة دواءميكوفينولات 500مجم 50 اقراصmycophenolate mofetil-sandoz 500 mg 50 tabs.

يتركب هذا الدواء من :mycophenolate mofetil