جليفيك 400 مجم 30 كبسولة

ما هو دواء جليفيك 400 مجم 30 كبسولة

جرعة دواءجليفيك 400 مجم 30 كبسولة

يستعمل دواء جليفيك 400 مجم 30 كبسولةglivec 400mg 30 f.c. tabs. antineoplastic antineoplastic

about imatinib -anticancer tyrosine- kinase inhibitor first generation. -mechanism of action of imatinib -imatinib is an inhibitor of multiple tyrosine kinases including kit abl and pdgfr( platelet-derived growth factor receptor) and inhibit phosphorelation. -indications for imatinib -1.chronic myelogenous leukemia -2.lymphoblastic leukemia (ph+all) -3.gastrointestinal stromal tumors -4.systemic mastocytosis -5.hypereosinophilic syndrome -6.dermatofibrosarcoma protuberans. -7.plexiform neurofibromas -interactions for imatinib -cyp3a4 inhibitors e.g. ketoconazole erythromycin clarithromycin itraconazole grapefruit juice)---- decrease metabolism---- increase imatinib exposure (40%) - -cyp3a4 inducers (dexamethasone phenytoin carbamazepine rifampicin phenobarbital or st. johns wort)----- increase metabolism---- decrease imatinib exposure (74%) - -cyp2d6 inhibitors (e.g. doxorubicin quinidine vinca alkaloids dextropropoxyphene)---- decrease metabolism---- increased

تركيبة دواءجليفيك 400 مجم 30 كبسولةglivec 400mg 30 f.c. tabs.

يتركب هذا الدواء من :imatinib