كارسيميا 400 مجم 10 اقراص

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جرعة دواءكارسيميا 400 مجم 10 اقراص

يستعمل دواء كارسيميا 400 مجم 10 اقراصcarcemia 400mg 10tabs. tyrosine- kinase inhibitor tyrosine- kinase inhibitor

about imatinib -anticancer tyrosine- kinase inhibitor first generation. -mechanism of action of imatinib -imatinib is an inhibitor of multiple tyrosine kinases including kit abl and pdgfr( platelet-derived growth factor receptor) and inhibit phosphorelation. -indications for imatinib -1.chronic myelogenous leukemia -2.lymphoblastic leukemia (ph+all) -3.gastrointestinal stromal tumors -4.systemic mastocytosis -5.hypereosinophilic syndrome -6.dermatofibrosarcoma protuberans. -7.plexiform neurofibromas -interactions for imatinib -cyp3a4 inhibitors e.g. ketoconazole erythromycin clarithromycin itraconazole grapefruit juice)---- decrease metabolism---- increase imatinib exposure (40%) - -cyp3a4 inducers (dexamethasone phenytoin carbamazepine rifampicin phenobarbital or st. johns wort)----- increase metabolism---- decrease imatinib exposure (74%) - -cyp2d6 inhibitors (e.g. doxorubicin quinidine vinca alkaloids dextropropoxyphene)---- decrease metabolism---- increased

تركيبة دواءكارسيميا 400 مجم 10 اقراصcarcemia 400mg 10tabs.

يتركب هذا الدواء من :imatinib